Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits
J. Clin. Invest. Lea Scheppke, et al. 118:2337 doi:10.1172/JCI33361 [
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Figure 4Laser vasoocclusion increases retinal vascular leakage more in wild-type (
Yes+/+,
Src+/+) than in
Src kinase–deficient (
Src–/–,
Yes–/–) mice.
(
Yes+/+/no laser, 1.39 ± 0.20;
Yes+/+/laser, 7.04 ± 1.33,
n = 35;
Yes–/–/no laser, 1.35 ± 0.24;
Yes–/–/laser 3.75 ± 0.50,
n = 36;
Src+/+/no laser, 1.49 ± 0.46;
Src+/+/laser, 8.44
± 2.66,
n = 13;
Src–/–/no laser, 2.04 ± 0.74;
Src–/–/laser, 2.77 ± 0.97,
n = 16. Error bars indicate SEM. *
P < 0.05; **
P < 0.01.
